Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp148 | Cell biology: osteoblasts and bone formation | ECTS2014

Expression of BDNF gene in the femur of aged vs adult rats

Camerino Claudia , Cannone Maria , Heiny Judy , Tricarico Domenico

Brain-derived neurotrophic factor (BDNF) has recently emerged as a factor able to concurrently target age related diseases as neurodegenerative disease, osteoporosis and metabolic syndrome. However the role of BDNF in the frailty syndrome associated with aging has never been investigated. The deletion of central BDNF gene in mice results in increased bone mass and in vitro experiments show that BDNF has a positive effect on bone. BDNF expression is mediated by estroge...