Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp146 | Cancer and bone: basic, translational and clinical | ECTS2013

Metabolomics identifies plasma biomarkers of multiple myeloma development and progression

Mariani Elisabetta , Fontana Francesca , Mari Silvia , Manteiga Jose Manuel Garcia , Marcatti Magda , Napoli Nicola , Camnasio Francesco , Fraschini Gianfranco , Caneva Enrico , Sitia Roberto , Musco Giovanna , Ciceri Fabio , Cenci Simone

Multiple myeloma is an incurable neoplastic disorder of plasma cells, which invade the bone marrow, secrete monoclonal immunoglobulins, and induce bone lesions, hypercalcemia, anemia and renal failure. The development of myeloma relies on vicious interactions with the bone microenvironment, a deeper knowledge of which is needed to identify prognostic markers and potential therapeutic targets. To achieve an unbiased, comprehensive assessment of the extracellular milieu of myelo...

ba0005p122 | Cancer and bone: basic, translational and clinical | ECTS2016

Acetate metabolism in Multiple Myeloma identifies 11C-Acetate PET as a novel strategy to image bone disease and response to treatment in preclinical models

Fontana Francesca , Ge Xia , Su Xinming , Xiang Jingyu , Cenci Simone , Civitelli Roberto , Shoghi Kooresh , Akers Walter , D'Avignon Andre , Shokeen Monica , Weilbaecher Katherine

Multiple Myeloma (MM) is a malignancy of Plasma Cells (PC), characterized by severe osteolytic lesions but poor 99Tc-MDP uptake in bone scans due to osteoblast inhibition. We hypothesized that high demands for membrane biosynthesis in tumour PC would enhance monocarboxylic acid anabolism and uptake, which could be exploited for treatment and molecular imaging. Here, we tested the efficacy of clinically available 11C-Acetate PET to detect myeloma and quant...

ba0005p452 | Other diseases of bone and mineral metabolism | ECTS2016

Micro-RNA expression profiling in Paget’s disease of bone

Bianciardi Simone , Merlotti Daniela , Sebastiani Guido , Valentini Marco , Gonnelli Stefano , Caffarelli Carla , Evangelista Isabella Anna , Cenci Simone , Nuti Ranuccio , Dotta Francesco , Gennari Luigi

Since their initial discovery, microRNAs (miRNAs) have emerged as critical post-transcriptional regulators of gene expression that are able to modulate bone remodeling. Nonetheless, despite the peculiar and aggressive phenotype of pagetic osteoclasts and the associated increase in osteoblast activity, whether deregulation of miRNAs is involved in Paget’s disease of bone (PDB) remains unknown. Here, we performed a serum miRNA expression profile (Taqman Human MicroRNA Array...

ba0005p108 | Cancer and bone: basic, translational and clinical | ECTS2016

Clinical and experimental evidence suggest a protective effect of Paget’s disease of bone against skeletal metastasization from solid tumors

Merlotti Daniela , Rucci Nadia , Rendina Domenico , Bianciardi Simone , Evangelista Isabella Anna , Ucci Argia , Rotatori Stefano , Sebastiani Guido , Dotta Francesco , Cenci Simone , Strazzullo Pasquale , Nuti Ranuccio , Teti Anna , Gennari Luigi

Paget’s disease of bone (PDB) is a common disorder of bone metabolism characterized by focal areas of excessive and rapid bone resorption and formation, leading to bone pain, deformity and fractures. Despite the well documented increase in the risk of primary bone tumors due to neoplastic degeneration of pagetic tissue, a large retrospective analysis suggested that patients with prostate cancer and PDB have delayed time to bone metastases and improved overall survival tha...