Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp110 | Cell biology: osteoblasts and bone formation | ECTS2014

Age-dependent loss of microvesicular galectin-3 and its consequences on bone formation in vitro and in vivo

Weilner Sylvia , Heimel Patrick , Keider Verena , Schraml Elisabeth , Weisz Florian , Chiang DML , Grillari-Voglauer Regina , Redl Heinz , Chen HY , Grillari Johannes

Introduction: Mesenchymal stem cells (MSCs) counteract the decline of physiologic functions but their regenerative power decreases with age. In particular osteogenic differentiation capacity of MSCs has been shown to decrease with age thereby contributing to slowed down bone formation and osteoporosis. While much is known about cellular aging of MSCs, little is known about extrinsic factors influencing their functionality. Here we set out to identify circulating factors of the...