Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p367 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

FGF23 and SCL are expressed in carotid plaques and the association between their circulating fractions and fractures differs in relation to comorbidity in elderly individuals

Rotatori Stefano , Corallo Claudio , Merlotti Daniela , Rendina Domenico , Bianciardi Simone , Patti Aurora , Gonnelli Stefano , Evangelista Isabella Anna , Lucani Barbara , Franci Maria Beatrice , Setacci Carlo , Strazzullo Pasquale , Nuti Ranuccio , Dotta Francesco , Gennari Luigi

Sclerostin (SCL) and FGF23 are osteocyte-secreted factors with a major role in bone homeostasis. Despite their skeletal effects and their association with fracture risk in some studies, variations in circulating levels were also described in patients with diabetes (DM), chronic renal failure (CRF) and/or cardiovascular disease (CVD). In order to provide further insight on the relationship between these osteocyte-derived factors, osteoporosis and cardio-metabolic disorders we a...