Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp253 | Chondrocytes and cartilage | ECTS2013

Can adrenomedullin be a potential osteoarthritis treatment?

Chatron-Colliet Aurore , Velard Frederic , Come Dominique , Lin Hilene , Ea Hang Korng , Liote Frederic

Objective: Chondrolysis, chondrocyte apoptosis, and local inflammation are described to exacerbate osteoarthritis development. We therefore aimed to investigate the effect of adrenomedullin (ADM) and its truncated peptide (22–52ADM) on in vitro and in vivo models. Both have exhibited anti-apoptotic and anti-inflammatory properties in collagen-induced arthritis (CIA) in mice.Methods: In normoxia or hypoxia (physiological condition),...

ba0003ht4 | (1) | ECTS2014

Sclerostin prevents mice from osteoarthritis despite high subchondral bone accretion

Bouaziz Wafa , Funck-Brentano Thomas , Lin Hilene , Marty Caroline , Come Dominique , Hay Eric , Cohen-Solal Martine

Purpose: Sclerostin, a Wnt inhibitor produced by osteocytes that regulate bone remodelling, might be involved in cartilage metabolism. Therefore, we assessed the effect of sclerostin in osteoarthritis using SOST-deficient mice.Methods: SOST-KO and wild type (WT) mice underwent partial meniscectomie (Mnx). Mice were sacrificed at 4, 6 or 9 weeks after Mnx to analyze i) bone volume (BV/TV) at the femoral condyle, ii) osteophyte volume (microCT), iii) carti...