Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p189 | Cell biology: osteoclasts and bone resorption | ECTS2016

Pathophysiological implication of Autotaxin on osteoclast function

Flammier Sacha , Gicquel Tristan , Duboeuf Francois , Peyruchaud Olivier , Coury Fabienne , Machuca-Gayet Irma

Autotaxin (ATX) is a secreted protein produced by various tissues in the body including the liver, adipose tissue and bone. Autotaxin (ATX) is an enzyme with a phospholipase D activity responsible for cleavage of lysophosphatidyl-choline (LPC) in lysophosphatidic acid (LPA). LPA is a bio phospholipid, which acts as a growth factor, affecting proliferation, differentiation, and migration. It has been shown that the biological effect of LPA could be the direct consequence of loc...