Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp191 | Cell biology: osteoblasts and bone formation | ECTS2013

Nuclear translocation of oxytocin receptor mediates increased gene expression in osteoblasts

Di Benedetto Adriana , Cuscito Concetta , Colaianni Graziana , Tamma Roberto , Nico Beatrice , Calvano Damiana , Zambonin Carlo , Corcelli Michelangelo , Zallone Alberta

The neuro-hypophiseal hormone oxytocin (OT) is a novel anabolic regulator of bone mass (Tamma et al. PNAS, 2009), upregulating expression of critical osteoblast transcription factors. These effects are mediated by oxytocin receptor, a GPCR expressed by osteoblasts. Recently an increasing number of reports indicates that GPCRs could be targeted to the nuclear membrane; prostaglandin receptors, endothelin receptors and β-adrenergic receptors among others (...

ba0003pp212 | Muscle, physical activity and bone | ECTS2014

New insights in the bone-muscle axis: the novel myokine irisin is involved in skeletal metabolism

Colaianni Graziana , Cuscito Concetta , Mongelli Teresa , Oranger Angela , Mori Giorgio , Brunetti Giacomina , Colucci Silvia , Cinti Saverio , Grano Maria

It has been recently reported that, after physical exercise activity, the skeletal muscle releases Irisin, the newly identified myokine able of driving transition of white adipocytes to brown, following a phenomenon known as the browning response. This result has suggested that skeletal muscle is crucial in the regulation of energy homeostasis, supporting the idea that it can be considered an endocrine organ that targets adipose tissue by promoting energy expenditure. In accor...

ba0005oc4.6 | Catabolism and metabolism | ECTS2016

The myokine Irisin improves bone quality and strength

Colaianni Graziana , Cuscito Concetta , Mongelli Teresa , Pignataro Paolo , Liu Peng , Lu Ping , Mori Giorgio , Brunetti Giacomina , Yuen Tony , Sun Li , Reseland Janne , Colucci Silvia , Zaidi Mone , Cinti Saverio , Grano Maria

Irisin is a hormone-like myokine secreted from skeletal muscle in response to exercise. Considering that an intimate relationship between skeletal muscle and bone has been well established and that physical exercise physiologically stimulates the skeleton strengthening, we explored the involvement of Irisin on bone metabolism.Our findings demonstrated that the myokine Irisin improves cortical bone mass and geometry in vivo, supporting the idea t...