Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp143 | Cell biology: osteoblasts and bone formation | ECTS2014

Utilization of L-mimosine in pulp regeneration: lessons from cell culture and tooth slice organ cultures

Muller Heinz-Dieter , Trimmel Katharina , Cvikl Barbara , Gruber Reinhard , Agis Hermann

After trauma or carious lesion dental pulp healing is difficult to predict. In addition systemic diseases like diabetes mellitus can impair the regenerative capacity. New regenerative strategies target prolyl hydroxylase (PHD) by pharmacological inhibitors to stimulate hard and soft tissue healing. PHD inhibitors such as L-mimosine (L-MIM) induce vascular endothelial growth factor (VEGF) production by promoting angiogenesis. However, it is unclear if L-MIM is a feasible tool t...