Searchable abstracts of presentations at key conferences on calcified tissues

ba0004p190 | (1) | ICCBH2015

Bone quality and quantity in Duchenne Muscular Dystrophy patients

Del Rio Luis , Winzenrieth Renaud , Di Gregorio Silvana

The aim of the study is to evaluate bone quantity (aBMD) and bone quality as assessed by TBS in DMD subjects.43 boys and girls suffering from DMD with a mean age 10.5±3.7 years and height and weight z-score (Zc) medians of −0.67 and 0.25 S.D. were included in the study. Spine DXA scans were obtained using a GE Lunar iDXA with software v13.31. Lumbar spine trabecular bone texture (TBS) was determined using Med-Imaps cust...

ba0004p191 | (1) | ICCBH2015

Evolution of bone quality and quantity in patients suffering from Duchenne Muscular Dystrophy

Del Rio Luis , Di Gregorio Silvana , Winzenrieth Renaud

The aim of the study is to evaluate, across time, if a bone microarchitectural texture modification exists or not and to evaluate its associations with other bone and body composition parameters.16 Spanish children suffering from DMD with a mean age 9.7±3.0 years and height and weight z-score of −0.76 and 0.16 SD were included in the study. Spine DXA scans and body composition scans were obtained using a GE Lunar Prodigy at baseline, ...

ba0006p077 | (1) | ICCBH2017

The role of bone age in the evaluation of trabecular bone score (TBS) of children and adolescents 5--19 years old

Guagnelli Miguel Angel , Ambrosi Regina , Lopez-Gonzalez Desiree , Winzenrieth Renaud , Del Rio Luis , Clark Patricia

Rationale: Trabecular Bone Score (TBS) is a texture-based tool analyzing DXA images in order to assess bone microarchitecture in the lumbar region. In pediatric population, definition of normative values has remained elusive due to the disparities of results in normal population, probably link to uncontrolled factors which impact bone microarchitecture and the nonlinear behavior of bone growth. Our objective was to evaluate TBS in healthy Mexican children and adolescents using...

ba0001pp277 | Genetics | ECTS2013

A genomic and transcriptomic approach to the high bone mass phenotype: evidences of heterogeneity and of additive effects of TWIST1, IL6R, DLX3, and PPARG

Sarrion Patricia , Mellibovsky Leonardo , Urreizti Roser , Civit Sergi , Cols Neus , Garcia-Giralt Natalia , Yoskovitz Guy , Aranguren Alvaro , Malouf Jorge , del Rio Luis , Guerri Roberto , Nogues Xavier , Diez-Perez Adolfo , Grinberg Daniel , Balcells Susana

The aims of this study were to establish the prevalence of the high bone mass (HBM) phenotype in a cohort of Spanish postmenapausal women (BARCOS); to determine whether any of the HBM cases carry LRP5 or DKK1 mutations; to test the hypothesis of an inverse correlation between the number of common variant risk alleles and HBM; and to characterize the expression of osteoblast-specific and Wnt pathway genes in primary osteoblast RNA samples from two HBM cases.</...

ba0005p234 | Genetics and Epigenetics | ECTS2016

SNP regulation of miRNA expression and its association with osteoporosis

De-Ugarte Laura , Caro-Molina Enrique , Rodriguez-Sanz Maria , Garcia-Perez M A , Olmos J M , Sosa-Henriquez Manuel , Perez-Cano Ramon , Gomez-Alonso Carlos , Del Rio Luis , Mateo-Agudo Jesus , Navarro-Casado Laura , Gonzalez-Macias Jesus , Del Pino-Montes Javier , Munoz-Torres Manuel , Diaz-Curiel Manuel , Malouf Jorge , Perez-Catrillon J L , Nogues Xavier , Garcia-Giralt Natalia , Diez-Perez Adolfo

Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotype variability. The aim of this study was to identify osteoporosis-related SNPs by affecting the expression levels of mature microRNAs.The first approach was to perform an association analysis of putative functional SNPs located in pri-miRNA sequences of bone-related microRNAs with the lumbar spine and femoral neck (FN) bone mineral den...