Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp150 | Cell biology: osteoblasts and bone formation | ECTS2014

PRKG1: A novel regulator of human skeletal (mesenchymal) stem cell differentiation

Jafari Abbas , Siersbaek Majken , Dobbelstein Matthias , Kassen Moustapha

Protein kinases are an important class of regulatory elements and pharmacological targets for treatment of a number of diseases including cancer, heart and lung diseases. However, their role in regulation of the skeletal (mesenchymal) stem cell (MSC) functions and bone formation is not fully understood. Thus, we performed functional screening of human kinome, using three siRNAs for each of the ~700 known kinases represented in the human genome. Activity of alkaline phosphatase...