ba0005p124 | Cancer and bone: basic, translational and clinical | ECTS2016
Amin Zarkesh Sayyed
, Docherty Freyja
, Eaton Colby
, Wang Ning
Rationale and hypothesis: In ~70% of advanced prostate cancer (PCa) patients, incurable bone metastases are a significant cause of morbidity and mortality. It has been shown that in models of PCa, bone metastases are initiated by a minor subset (<1% of total cell population) that are mitotically quiescent and which have undergone epithelial to mesenchymal transition (EMT). Recent studies have shown that various P2 receptors regulate invasiveness/EMT in different types of c...