Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp190 | Genetics | ECTS2014

Premature aging of bone is delayed by dietary restriction

van der Eerden Bram , Botter Sander , Reiling Erwin , Hoeijmakers Jan , Dolle Martijn , van Leeuwen Johannes

Loss of genomic maintenance contributes to aging, as exemplified by mutations in Ercc DNA repair proteins that lead to a plethora of progeroid syndromes of which some display accelerated bone loss. It is generally accepted that dietary restriction (DR) increases life span and improves organ function. We therefore assessed the impact of DR on life span and bone mass in WT and bona fide prematurely aging hypomorphic Ercc-deficient mice (Ercc1−/Δ).<...