Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp8 | Clinical case posters | ECTS2013

Phenotypic change in a patient with hypophosphatasia with the onset of renal failure

Cundy Tim , Michigami Toshimi , Tachikawa Kanako , Dray Michael , Collins John

Hypophosphatasia is a recessively inherited disorder with a wide phenotypic manifestation ranging from lethality in neonates to asymptomatic in adults. The severity of the phenotype is largely determined by the nature of the ALPL mutations. We describe a previously asymptomatic adult whose phenotype dramatically changed after he developed renal failure. A 50-year-old man was diagnosed with IgA nephropathy. At age 52 (eGFR 50 ml/min) he suffered his first metatarsal fr...

ba0001pp21 | Arthritis and other joint diseases: translational and clinical | ECTS2013

Monosodium urate crystals inhibit tenocyte viability and function: implications for periarticular involvement in chronic gout

Chhana Ashika , Callon Karen , Dray Michael , Pool Bregina , Naot Dorit , Gamble Greg , Coleman Brendan , McQueen Fiona , Cornish Jillian , Dalbeth Nicola

Background: In patients with gout, urate deposition has been observed both adjacent to and within tendons, suggesting that monosodium urate monohydrate (MSU) crystals are likely to be in direct contact with tenocytes, the stromal cells of tendons. The aim of this study was to determine the effects of MSU crystals on tenocyte viability and function.Methods: Cultures of primary rat tenocytes were prepared from Wistar rat tails. Primary human tenocytes were...