Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp73 | Bone development/growth and fracture repair | ECTS2013

Feasibility of local CD133+ cell transplantation to avoid non-unions in biological impaired bone healing

Dienelt Anke , Sass Andrea F , Preininger Bernd , Schmidt-Bleek Katharina , Duda Georg N

The clinical orthopaedic problem of delayed healing or non-union after complex fractures affects 5–10% of all patients, especially within the elderly population. Recently several in vitro studies showed that CD133+ cells bare angiogenic capacities and contribute to a better outcome concerning ischemia induced angiogenesis in vivo. A local administration of these specific cells to the fracture gap appears feasible as a new treatment option for biological ...

ba0005p71 | Bone development/growth and fracture repair | ECTS2016

Transcriptional analysis of bone healing in mouse: an insight into biological and chronological overlapping genes

Malhan Deeksha , Schmidt-Bleek Katharina , Duda Georg , Heiss Christian , El Khassawna Thaqif

The healing of skeletal fractures involves a cascade of overlapping cellular events. This study aims to deepen the understanding of molecular networks orchestrating these events.Standard closed fracture in the left femur of male 8–10 weeks old C57BL/6N mice were analyzed at (day=D) D3, D7, D10, D14, D21 & D28 post fracture (N=5/time point). Total RNA was prepared for whole genome expression profiling using Illumina μ-array kit. Dat...

ba0001pp75 | Bone development/growth and fracture repair | ECTS2013

Interplay of physical and biological cues in the regeneration of critical-sized bone defects

Cipitria Amaia , Reichert Johannes C , Lange Claudia , Schell Hanna , Mehta Manav , Wagermaier Wolfgang , Zaslansky Paul , Fratzl Peter , Hutmacher Dietmar W , Duda Georg N

The transplantation of autologous bone graft represents the ‘gold standard’ treatment for large bone defects, despite the harvesting co-morbidity and limited availability. An alternative scaffold-based approach is presented. Our aim was to investigate to what degree structured scaffolds alone, or in combination with biological stimuli, allow guiding tissue regeneration. Scaffolds consisting of medical-grade polycaprolactone and tricalcium phosphate microparticles, co...