Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp41 | Bone development/growth and fracture repair | ECTS2014

Exosomes derived from human platelet lysate affect MSC functions in vitro

Torreggiani Elena , Perut Francesca , Roncuzzi Laura , Baldini Nicola

Introduction: Despite the popularity of platet lysate (PL) treatments in orthopaedics, the mechanism of action and the effectiveness of this therapeutic tool is still controversial. So far, the activity of PL has been associated with different growth factors (GFs) released upon platelet degranulation. However, PL activity might also be due to the efficient cell to cell transport system of GF and other bioactive molecules by their encapsulation into exosomes. In this study, we ...

ba0005p202 | Cell biology: osteoclasts and bone resorption | ECTS2016

The effect of potassium citrate on human primary osteoclasts in vitro

Torreggiani Elena , Massa Annamaria , Di Pompo Gemma , Granchi Donatella , Baldini Nicola

An increasing amount of scientific evidence suggests that western diet is a risk factor for osteopenia and osteoporosis. Indeed, metabolic acidosis, occurring after high levels of protein intake, may adversely impact on the skeleton by disrupting calcium metabolism, and leads to a decrease of bone mineral density (BMD). Currently, the prevention and treatment of osteopenia and osteoporosis are mainly based on lifestyle modifications (i.e. exercise, quitting smoking and ensurin...