Searchable abstracts of presentations at key conferences on calcified tissues

ba0002op15 | (1) | ICCBH2013

Dissecting the role of osteoblast derived nitric oxide in bone remodeling

Grover Monica , Nagamani Sandesh , Erez Ayelet , Lee Brendan

Background: Bone accrual during adolescence is the main contributor to peak bone mass. Bone remodeling is a balance between bone formation and resorption as directed by osteoblast and osteoclast activity, respectively. nitric oxide (NO) is a potent regulator of bone remodeling via mediating effects of cytokines, estrogen and mechanical strain. NO is synthesized from the conversion of L-arginine to L-citrulline by the enzyme nitric oxide synthase (...