Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp111 | Cell biology: osteoblasts and bone formation | ECTS2014

Osteopontin as a novel substrate for proprotein convertase 5/6 (PCSK5) in bone

Hoac Betty , Susan-Resiga Delia , Essalmani Rachid , Marcinkiweicz Edwidge , Barros Nilana , Seidah Nabil , McKee Marc

Proprotein convertase PC5/6 (Pcsk5) is expressed in mouse bone and Pcsk5 epiblast-specific conditional knockout mice have a bone phenotype displaying small size, delayed ossification and additional thoracic segments and ribs. Some features are attributed to growth and developmental factor 11 (GDF11) – a known substrate for PC5/6 – while the delayed mineralization has yet to be explained. Osteopontin (OPN) is a bone matrix protein with roles in miner...