Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp119 | Cell biology: osteoblasts and bone formation | ECTS2014

Effect of osteoporosis in the transcriptional profile of osteoblastic cells from bone marrow and calvaria of ovariectomized rats

Semeghini Mayara Sgarbi , de Azevedo Fernanda Grilo , de Assis Amanda Freire , Siessere Selma , Beloti Marcio Mateus , Rosa Adalberto Luiz , Fernandes Roger Rodrigo , Passos Geraldo Aleixo , Prado Karina Fittipaldi Bombonato

Changes in the ability of self-renewal and differentiation of mesenchymal stem cells may be affected by osteoporosis. The aim of this investigation was to compare the transcriptional profile of mRNAs and miRNAs of osteoblastic cells from calvaria and bone marrow of female rats after ovariectomy. Following the approval by ethics committee, 18 wistar rats were divided into control (sham) and ovariectomized groups. After 150 days, both groups were sacrificed to collect the femurs...