Searchable abstracts of presentations at key conferences on calcified tissues

ba0003oc4.5 | Genetics of bone disease | ECTS2014

Bone microarchitecture, geometry and volumetric BMD assessed using HR-pQCT in adult patients with hypophosphatemic rickets

Shanbhogue Vikram , Hansen Stinus , Folkestad Lars , Brixen Kim , Beck-Nielsen Signe

Although X-linked hypophosphatemic rickets (XLH) is characterized by hypophosphatemia leading to a generalized mineralization defect with rickets (and/or osteomalacia), densitometric studies point towards a tendency towards an elevated bone mineral density (BMD). The aim of this cross-sectional in vivo study was to assess bone geometry, volumetric BMD (vBMD), microarchitecture and estimated bone strength using high-resolution peripheral quantitative computed tomograph...

ba0005p436 | Other diseases of bone and mineral metabolism | ECTS2016

Determinants of health related quality of life in adults with osteogenesis imperfecta

Hald Jannie Dahl , Folkestad Lars , Harslof Torben , Brixen Kim , Langdahl Bente

Osteogenesis imperfecta (OI) is a systemic connective tissue caused by mutations in collagen type 1 related genes. Patients with OI suffer from multiple fractures and various degrees of growth deficiency and bone deformity. Other symptoms are early hearing loss, abnormal dental tissue and hypermobility. It is not known whether the systemic effect of a defect collagen type 1 influences the quality of life in people with OI. We aimed to investigate health related quality of life...

ba0003pp362 | Other diseases of bone and mineral metabolism | ECTS2014

Osteogenesis imperfecta in adults: a cross sectional trial

Hald Jannie Dahl , Folkestad Lars , Andersen Jane , Harslof Torben , Lund Allan , Jens-Erik Beck Jensen , Brixen Kim , Langdahl Bente

Osteogenesis imperfecta (OI) is a hereditary disease with a generalized involvement of the connective tissue caused by collagen type 1 mutations. The clinical appearance is broad with fractures as the key symptom. Only few genotype–phenotype correlations have been established. We aim to characterize the Danish OI population thoroughly including DXA and HRpQCT, anthropometry, patient history, and genetic background.This cross-sectional study includes...