Searchable abstracts of presentations at key conferences on calcified tissues

ba0005oc2.6 | Bone mass and bone strength Wnt signalling | ECTS2016

N-cadherin maintains osteoprogenitor number and restrains Wnt signaling in osteoblasts

Fontana Francesca , Salazar Valerie , Brecks Cynthia , Revollo Leila , Mbalaviele Gabriel , Civitelli Roberto

We have shown that genetic ablation of Cdh2 (N−cadherin gene) in osteolineage cells results in osteopenia and decreased osteoprogenitor number. Paradoxically, others have shown that mice overexpressing Cdh2 in osteoblasts are also osteopenic; an action linked to a negative effect of N−cadherin (Ncad) on Wnt signaling, via sequestration of low density lipoprotein receptor−related protein−...

ba0001pp146 | Cancer and bone: basic, translational and clinical | ECTS2013

Metabolomics identifies plasma biomarkers of multiple myeloma development and progression

Mariani Elisabetta , Fontana Francesca , Mari Silvia , Manteiga Jose Manuel Garcia , Marcatti Magda , Napoli Nicola , Camnasio Francesco , Fraschini Gianfranco , Caneva Enrico , Sitia Roberto , Musco Giovanna , Ciceri Fabio , Cenci Simone

Multiple myeloma is an incurable neoplastic disorder of plasma cells, which invade the bone marrow, secrete monoclonal immunoglobulins, and induce bone lesions, hypercalcemia, anemia and renal failure. The development of myeloma relies on vicious interactions with the bone microenvironment, a deeper knowledge of which is needed to identify prognostic markers and potential therapeutic targets. To achieve an unbiased, comprehensive assessment of the extracellular milieu of myelo...

ba0005p122 | Cancer and bone: basic, translational and clinical | ECTS2016

Acetate metabolism in Multiple Myeloma identifies 11C-Acetate PET as a novel strategy to image bone disease and response to treatment in preclinical models

Fontana Francesca , Ge Xia , Su Xinming , Xiang Jingyu , Cenci Simone , Civitelli Roberto , Shoghi Kooresh , Akers Walter , D'Avignon Andre , Shokeen Monica , Weilbaecher Katherine

Multiple Myeloma (MM) is a malignancy of Plasma Cells (PC), characterized by severe osteolytic lesions but poor 99Tc-MDP uptake in bone scans due to osteoblast inhibition. We hypothesized that high demands for membrane biosynthesis in tumour PC would enhance monocarboxylic acid anabolism and uptake, which could be exploited for treatment and molecular imaging. Here, we tested the efficacy of clinically available 11C-Acetate PET to detect myeloma and quant...