Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp116 | Cell biology: osteoblasts and bone formation | ECTS2014

Inhibitory effect of GH on the adipogenic commitment of mesenchymal stromal cells derived from human trabecular bone

Bolamperti Simona , Spinello Alice , Sauer Aisha , GianLuigi Moro , Ometti Marco , Fraschini Gianfranco , Guidobono Francesca , Rubinacci Alessandro , Villa Isabella

Besides its well known effect on longitudinal bone growth, GH plays a role in the maintenance of adult bone mass. As aging progresses GH levels decline, bone mass decreases and mesenchymal precursors show a reduced osteogenic differentiation capacity resulting in an increase in bone marrow adipocytes. We investigated the effect of GH on MSC differentiation and the possible involvement of microRNA in this process. Human MSC derived from trabecular specimens, waste material of o...

ba0001pp146 | Cancer and bone: basic, translational and clinical | ECTS2013

Metabolomics identifies plasma biomarkers of multiple myeloma development and progression

Mariani Elisabetta , Fontana Francesca , Mari Silvia , Manteiga Jose Manuel Garcia , Marcatti Magda , Napoli Nicola , Camnasio Francesco , Fraschini Gianfranco , Caneva Enrico , Sitia Roberto , Musco Giovanna , Ciceri Fabio , Cenci Simone

Multiple myeloma is an incurable neoplastic disorder of plasma cells, which invade the bone marrow, secrete monoclonal immunoglobulins, and induce bone lesions, hypercalcemia, anemia and renal failure. The development of myeloma relies on vicious interactions with the bone microenvironment, a deeper knowledge of which is needed to identify prognostic markers and potential therapeutic targets. To achieve an unbiased, comprehensive assessment of the extracellular milieu of myelo...