Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p249 | Genetics and Epigenetics | ECTS2016

Identification of epigenomic regulators of osteoblast function

Henaff Carole Le , Partridge Nicola , Jehan Frederic , Geoffroy Valerie

Molecularly characterized epigenetic networks that control bone formation and are altered during aging are necessary to uncover new potential targets for osteoanabolic therapy. Our contribution to the iBONE consortium is to identify osteoanabolic epigenomic regulators by screening which are involved in osteoblast phenotype and differentiation. This study will be done by a 3 step approach including: siRNA screening for epigenomic regulators of osteoblastic differentiation and v...

ba0003pp288 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

Decrease in expression of MMP3 in osteoblast protects against bone loss

Zarka-Prost-Dumont Mylene , Jehan Frederic , Ostertag Agnes , de Vernejoul Marie-Christine , Geoffroy Valerie

Osteoblastic MMPs are important actors of bone remodeling. We showed previously that osteoblast specific overexpression of TIMP1, an inhibitor of MMPs, prevents the bone loss induced by ovariectomy mainly through inhibition of bone resorption. We hypothesized that inhibition of the MMP3 could be implicated in the protective effect of TIMP1 and that MMP3 polymorphisms located in the proximal promoter of MMP3 gene could be associated to post-menopausal bone loss in women.<p ...