Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp144 | Cell biology: osteoblasts and bone formation | ECTS2014

Pro-osteogenic properties of nacre extract on two cell lines, primary human osteoblasts and MC3T3-E1 cell line

Brion Alice , Zhang Ganggang , Piet Marie-Helene , Moby Vanessa , Bianchi Arnaud , Dossot Manuel , Mainard Didier , Galois Laurent , Gillet Pierre , Rousseau Marthe

Nacre, or mother of pearl, is a promising natural biocompatible biomaterial consisting of aragonite (97%) and of organics (3%) and capable to increase the cell osteogenic activity. It has been established that osteoarthritic osteoblasts present a mineralization defect and, to date, only a few molecules (vitamin D3 and bone morphogenetic protein2) could improve the mineralization potential of this cell type. In this context, we evaluated the impact of nacreous molecules on the ...

ba0005p148 | Cell biology: osteoblasts and bone formation | ECTS2016

Cationic nacre ethanol soluble matrix has an osteoanabolic effect on human subchondral osteoarthritic osteoblasts and MC3T3-E1 cell line

Zhang Ganggang , Brion Alice , Piet Marie-Helene , Moby Vanessa , Bianchi Arnaud , Mainard Didier , Galois Laurent , Aubriet Frederic , Carre Vincent , Gillet Pierre , Rousseau Marthe

Nacre is able to induce bone-forming cells mineralization, and gains widespread interest in bone regeneration. While, the osteoinductive compounds are not identified yet. The nacre extract, ethanol soluble matrix (ESM), was proven having the capacity to induce the mineralization of mouse MC3T3-E1 cells and to restore mineralization defect in human osteoarthritic osteoblasts. Being tested on the two cells, ESM could induce the formation of mineralization nodules, identified as ...