Searchable abstracts of presentations at key conferences on calcified tissues

ba0001opc1.2 | ECTS 50th Anniversary Symposium: 50 years of research in bone and mineral metabolism | ECTS2013

50 Years of bone imaging

Genant Harry

Considerable progress has been made over the past half century in the development of imaging methods for assessing the skeleton noninvasively or nondestructively, so that osteoporosis can be detected early, its progression and response to therapy monitored, and the risk of fracture determined. Clinicians and researchers can now evaluate the peripheral, central, or entire skeleton as well as the trabecular, cortical, and endosteal envelopes with a high degree of accuracy and pr...

ba0001pp451 | Osteoporosis: treatment | ECTS2013

Estimation of vertebral and femoral strength during the first three years of denosumab therapy using an alternative smooth non-linear finite element methodology

Zysset Philippe , Pahr Dieter , Engelke Klaus , Genant Harry , McClung Michael , Kendler David , Recknor Christopher , Kinzl Michael , Schwiedrzik Jakob , Museyko Oleg , Wang Andrea , Libanati Cesar

Denosumab subcutaneous administration every 6 months reduced the incidence of new fractures in postmenopausal women with osteoporosis by 68% at the spine and 40% at the hip over 36 months compared with placebo in the FREEDOM study (Cummings et al., NEJM, 2009:361:756). This efficacy was supported by differential improvements from baseline in vertebral and femoral strength at 36 months (18.2 and 8.6%, respectively) estimated by an established voxel-based finit...

ba0003pp239 | Osteoporosis: evaluation and imaging | ECTS2014

Impact of metal artefacts in QCT of the hip caused by a contralateral Gamma type nail: an ex vivo study

Engelke Klaus , Bouler Nicolas , Fuerst Oleg Museyko , Parratte Sebastien , Fuerst Thomas , Pion Francois-Xavier , Champsaur Pierre , Genant Harry , Corroller Thomas Le

Introduction: Gamma type nails are routinely used for the fixation of intertrochanteric fractures of the proximal femur. QCT at the hip is an advanced method that is increasingly being used to estimate BMD and determine the future fracture risk. Yet, implants cause metal artefacts (MA) in CT images, even at the contralateral side due to the high absorption of metal, which may impair BMD accuracy.Methods: Three human cadavers were scanned first without an...

ba0005oc3.1 | Clinical trials, FGF-23 and focal osteoporosis | ECTS2016

Effect of odanacatib on bone density and estimated bone strength in postmenopausal women: a CT-based sub-study of the phase 3 long-term odanacatib fracture trial (LOFT)

Langdahl Bente , De Villiers Tobias , Keaveny Tony M , Engelke Klaus , Genant Harry , Ather Shabana , Giezek Hilde , Lombardi Antonio , Leung Albert , de Papp Anne

Odanacatib (ODN), a selective oral inhibitor of cathepsin K, is in development for the treatment of osteoporosis. In the Phase 3, Long-Term ODN Fracture Trial (LOFT; NCT00529373), ODN significantly reduced fracture risk. This imaging sub-study primarily investigated the effect of ODN on volumetric BMD (vBMD) of the lumbar spine (LS) and total hip (TH) using quantitative computed tomography (QCT).Women aged ≥65 without baseline radiographic vertebra...