Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp496 | Other diseases of bone and mineral metabolism | ECTS2013

The miR-221/222 family regulates vascular smooth muscle cell calcification

Mackenzie Neil , Zhu Dongxing , Genever Paul , MacRae Vicky

The process of vascular calcification shares many similarities with that of skeletal mineralisation, and involves the phenotypic trans-differentiation of vascular smooth muscle cells (VSMCs) to osteoblastic and chondrocytic cells within a calcified environment. Various microRNAs (miRs) are known to regulate cell differentiation, however their role in mediating VSMC calcification has yet to be fully understood.Murine VSMCs were cultured for up to 28 days ...