Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp173 | Cell biology: osteoclasts and bone resorption | ECTS2014

Inhibition of bone remodeling by bisphosphonate displaces the plasma cell niche into the spleen

Teufel Stefan , Grotsch Bettina , Luther Julia , Schinke Thorsten , Amling Michael , Schett Georg , Mielenz Dirk , David Jean-Pierre

Bone marrow is the main hematopoietic organ of adults. There, hematopoietic stem cells from which all hematopoietic lineages can be generated are preferentially homing. Importantly, bone provides niches for early B cell differentiation and survival of long-lived plasma cells that produced antibodies. Thus, that perturbing bone homeostasis might impact B cell function and antibody production is a highly relevant hypothesis for patients receiving antiresorptive drugs.<p clas...

ba0005p147 | Cell biology: osteoblasts and bone formation | ECTS2016

Skin-derived IL-17A induces bone loss in the absence of adaptive immunity

Uluckan Ozge , Schnabl Jakob , Jimenez Maria , Jeschke Anke , Karbach Susanne , Schinke Thorsten , Waisman Ari , Schett Georg , Wagner Erwin

Inflammatory stimuli can lead to bone loss by mechanisms that are not well understood. We recently showed that skin inflammation induces bone loss in mice and humans. In psoriasis, one of the prototypic IL-17A-mediated inflammatory human skin diseases, low bone formation and bone loss correlates with increased serum IL-17A levels. Similarly, in two mouse models with chronic IL-17A-mediated skin inflammation, K14-IL17Aind and JunB&...

ba0003ht5 | (1) | ECTS2014

Skin inflammation causes bone loss with reduced bone formation through systemic IL-17A release

Uluckan Ozge , Keller Johannes , Karbach Susanne , Croxford Andrew , Finzel Stephanie , Koenders Marije , Berg Wim Van Den , Amling Michael , Waisman Ari , Schett Georg , Wagner Erwin

Patients with chronic inflammatory diseases such as psoriasis are at high risk for developing osteoporosis. Psoriatic arthritis patients exhibit bone loss caused by increased bone resorption through activation of osteoclasts. However, it is not clear whether psoriasis can lead to bone loss in the absence of arthritis. Using mouse models with skin inflammation as well as psoriasis patient samples, we show that increased circulating IL-17A from the inflamed skin triggers bone lo...