Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp128 | Cell biology: osteoblasts and bone formation | ECTS2014

Vitamin K2 (MK-7) is involved in bone and energy homeostasis: Effects on osteoblast, adipocyte and β-cell regulatory loops

Gordeladze Jan Oxholm , Reseland Janne Elin , Moller Mona

Uncarboxylated osteocalcin, allegedly via G-protein coupled receptors, interacts with adipocytes and pancreatic β-cells, thus affecting metabolic homeostasis. Here, we demonstrate that MK-7 directly and indirectly, via osteocalcin, modulates the endocrine functions of both β-cells and adipocytes.• It was shown (by applying the Mir@nt@n-based emulation algorithm) that MK-7 was involved in a network of intracellular regulat...