Searchable abstracts of presentations at key conferences on calcified tissues

ba0002p81 | (1) | ICCBH2013

Reference point indentation testing detects age-related changes in tissue mechanical properties in mice

Forbes Mhairi , Bishop Nick , Grabowski Peter

Objectives: The ability to discriminate bone fractures that result from non-accidental injuries and those that result from underlying bone fragility is limited by the lack of clinical instrumentation to directly measure bone mechanical properties. The BioDent Hfc (Active Life Scientific) is an experimental device that has been validated for measuring cortical bone fracture resistance in adults. We are currently developing protocols to test the feasibility of its use in infants...

ba0005p246 | Genetics and Epigenetics | ECTS2016

In a population based association study: IAPP gene variants are not associated with bone phenotypes in elderly women

Mitchell Adam , Grabowski Peter , Luthman Holger , Akesson Kristina , McGuigan Fiona

Skeletal strength, maintained through bone remodelling, is regulated through complex communication networks between bone cells and other tissues including endocrine cells. Bone also functions as an endocrine organ in its own right. The peptide hormone amylin (or Islet Amyloid Polypeptide (IAPP)), has links to both bone and energy metabolism. A member of the calcitonin family of peptides, it is co-secreted with insulin from pancreatic β-cells and is linked with diabetes-as...

ba0001pp57 | Bone biomechanics and quality | ECTS2013

Role of receptor activity modifying protein 3 in the response of bone to mechanical loading

Livesey Matthew , Pacharne Suruchi , Wang Ning , Grabowski Peter , Yang Lang , Richards Gareth , Skerry Tim

Adaptive responses of the skeleton to loading changes architecture and physical properties in order to optimise strength for function. However, bone is subjected to many local and circulating osteotropic factors, most acting on G-protein coupled receptors. Receptor activity modifying protein-3 is a single trans-membrane domain receptor accessory protein, which aids in trafficking of calcitonin and calcitonin-like receptors to the cell surface and changes ligand selectivity. As...

ba0002oc22 | Miscellaneous | ICCBH2013

Prolidase deficient mice are osteoporotic in early life

Foster Sarah , Grabowski Peter , Gallagher Orla , Besio Roberta , Rossi Antonio , Bishop Nick , Forlino Antonella

Background: Proline and hydroxyproline account for ~25% of aminoacids in collagen., Prolidase (peptidase D (EC, cleaves iminodipeptides with a C-terminal proline or hydroxyproline, playing a major role in collagen catabolism. Mice with prolidase deficiency (PD) present with varied phenotypes including reduced size compared to wild-type littermates. We measured structural and mechanical properties of bones in PD mice.Methods: Whole femurs from ...

ba0002p86 | (1) | ICCBH2013

Assessing bone quality and fracture resistance in children using microindentation

Forestier-Zhang Lydia , Grabowski Peter , Gallagher Orla , Patel Ameeta , Madan Sanjeev , Arundel Paul , Bishop Nick

Background: At present, clinical assessment of bone strength in children predominantly relies bone mass measurement using absorptiometry (DXA) or QCT densitometric approaches. However, bone strength is not only dependent on mass/density, but also structural and material mechanical properties. Currently no technique measures bone mechanical properties. Recently, a new micro-indentation device, the reference point indentation (RPI) instrument has been validated for the measure o...