Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp132 | Cancer and bone: basic, translational and clinical | ECTS2013

The central role of the histone demethylase JHDM1D in the regulation of tumor associated genes in bone tumor-related cells

Thaler Roman , Spitzer Silvia , Haider Florian , Karlic Heidrun , Klaushofer Klaus , Varga Franz

Tumor development occurs often by over-activation of members of the RAS-oncogene family (small GTPases (sGTPs)). By blocking the mevalonate pathway, aminobisphosphonates (BPs), and statines prevent activation of GTPs by inhibiting their post-translational prenylation. As we have shown, this induces apoptosis in U2OS osteosarcoma cells by re-activation of FAS expression via epigenetic DNA demethylation (1).The histone demethylase JHD...