Searchable abstracts of presentations at key conferences on calcified tissues

ba0003oc4.5 | Genetics of bone disease | ECTS2014

Bone microarchitecture, geometry and volumetric BMD assessed using HR-pQCT in adult patients with hypophosphatemic rickets

Shanbhogue Vikram , Hansen Stinus , Folkestad Lars , Brixen Kim , Beck-Nielsen Signe

Although X-linked hypophosphatemic rickets (XLH) is characterized by hypophosphatemia leading to a generalized mineralization defect with rickets (and/or osteomalacia), densitometric studies point towards a tendency towards an elevated bone mineral density (BMD). The aim of this cross-sectional in vivo study was to assess bone geometry, volumetric BMD (vBMD), microarchitecture and estimated bone strength using high-resolution peripheral quantitative computed tomograph...

ba0005p299 | Osteoporosis: evaluation and imaging | ECTS2016

Bone geometry and microarchitecture in patients with anorexia nervosa: a possible role of mechanical loading on cortical bone structure

Frolich Jacob , Hansen Stinus , Al-Dakhiel Winkler Laura , Andresen Andreas , Hermann Anne Pernille , Stoving Rene K.

Objective: To assess the effect of mechanical loading in anorexia nervosa (AN) in vivo, by comparing bone geometry and microarchitecture in weight bearing versus non-weight bearing bone.Subjects and methods: A total of 26 female patients with AN, and 26 female controls matched on age and height were included. Bone geometry, volumetric bone mineral density (vBMD) and microarchitecture were assessed using HR-pQCT (Scanco Medical, Brütisellen,...

ba0005p252 | Genetics and Epigenetics | ECTS2016

Mitochondrial DNA point mutation is associated with lower bone turnover markers

Langdahl Jakob H. , Hansen Stinus J. , Andersen Per H. , Yderstraede Knud B. , Vissing John , Duno Morten , Frederiksen Anja L. , Frost Nielsen Morten

Introduction: Mitochondrial dysfunction is associated with several clinical outcomes including diabetes and myopathy and is implicated in the human aging process. We previously showed that the mitochondrial DNA point mutation mtDNA3243A>G is associated with lower BMD and altered bone structure. The aim of this study was to assess bone turnover markers in individuals with the mutation and controls.Methods: We recruited 45 patients (29 female, 16 male)...