Searchable abstracts of presentations at key conferences on calcified tissues

ba0001oc2.3 | Bone quality and fracture repair - animal models | ECTS2013

Low-magnitude high-frequency vibration improves fracture healing in aged, ovariectomized mice

Wehrle Esther , Bindl Ronny , Wehner Tim , Heilmann Aline , Fischer Lena , Noland Jarrod , Amling Michael , Ignatius Anita

Introduction: Fracture healing is impaired in aged and osteoporotic patients. Because bone formation is tightly regulated by the mechanical conditions in the fracture gap and because suitable mechanical stimuli improve fracture healing (Claes et al. 1998), we investigated whether low-magnitude high-frequency vibration (LMHFV; Rubin et al. 2004) is able to improve delayed fracture healing induced by age and ovariectomy in mice.Sudy desig...

ba0003pp46 | Bone development/growth and fracture repair | ECTS2014

Midkine deficiency significantly delayed chondrogenesis during fracture healing in mice

Haffner-Luntzer Melanie , Heilmann Aline , Rapp Anna , Schinke Thorsten , Amling Michael , Ignatius Anita , Liedert Astrid

One growth factor that potentially plays a role in fracture healing is midkine (Mdk). Mdk is expressed in chondrocytes during bone repair (Ohta et al. 1999) and has been shown to influence bone mass and mechanotransduction (Neunaber et al. 2010, Liedert et al. 2011). The aim of the present study was to evaluate the effects of Mdk-deficiency on bone repair in a standardized mouse femur osteotomy model.Mdk-deficient and wildtype ...