Searchable abstracts of presentations at key conferences on calcified tissues

ba0007is7 | (1) | ICCBH2019

Effect of vitamin D on body composition

Weiler Hope A

In Canada, and many other countries, a vitamin D supplement of 400 IU/day is recommended for breastfed infants and staple foods are fortified with vitamin D in accordance with public health policy for the primary prevention of rickets. Both vitamin D receptors and 1-alpha hydroxylase enzymes are expressed in human muscle, implicating vitamin D status and metabolism in growth and development. In a randomized dose response study of vitamin D supplementation (400, 800, 1200, or 1...

ba0006p142 | (1) | ICCBH2017

Walking within 12 months of age is related to higher whole body lean mass and bone mineral density in children at 3 years of age

Weiler Hope , Vanstone Catherine

Gross motor development is positively associated with bone mineral density in teenagers and is thought to be mediated by lean mass. Age at walking is an accepted milestone in motor development, achieved by 50% of infants by 12 mo of age according to the WHO Motor Development Study.Objective: To examine if walking within 12 mo of age is related to bone mineral density (BMD) and if this relationship is mediated by lean mass.Methods: ...

ba0006p153 | (1) | ICCBH2017

Vitamin D intake and status in children 2–18 years: a meta-analysis

Brett Neil , Weiler Hope

Evidence is unclear on the effect of vitamin D intake on vitamin D status in children.Objective: In a meta-analysis, investigate the effect of vitamin D supplements and/or fortified foods on vitamin D status, using the biomarker 25-hydroxyvitamin D (25(OH)D) in children 2–18 years.Methods: Eligible studies were randomized placebo-controlled trials, published in English, in children 2–18 years that compared vitamin D suppl...

ba0006oc6 | (1) | ICCBH2017

Lean mass accretion increases during summer and positively associates with vitamin D status in healthy children 2-8 years

Brett Neil , Vanstone Catherine , Weiler Hope

The relationship between vitamin D status and lean mass accretion in young children is not well understood.Objective: To explore vitamin D status in relation to lean mass outcomes over 12 mo in children 2–8 years.Methods: This was a secondary analysis of trial data ( NCT02097160, NCT02387892) in Montreal, Canada. Children consumed their normal vitamin D intake for 6 mo (Apr–Oct 2014, n=39) and ...

ba0006p140 | (1) | ICCBH2017

Bone mineral accretion is increased during winter and is positively related to lean mass accretion in healthy children 2--8 years

Brett Neil , Vanstone Catherine , Weiler Hope

In children, it is not well understood how bone mineral accretion is related to lean mass accretion and vitamin D status.Objective: To explore over 12 mo how bone parameters relate to lean mass and vitamin D metabolites in children 2–8 years.Methods: This was a secondary analysis of data from 2 trials ( NCT02097160, NCT02387892) in Montreal, Canada. Children consumed their normal diet without vitamin D suppl...

ba0002p61 | (1) | ICCBH2013

Elevated FGF23 levels in premature infants without excessive phosphaturia

Fatani Tarah , Binjab Asma , Weiler Hope , Sharma Atul , Rodd Celia

Preterm infants develop reduced bone mass and fragility fractures. Nevertheless, normal ranges in preterm infants are poorly defined for concentrations of vitamin D; its isomers (C3α-epimer of 25(OH)D3) and metabolites (24, 25(OH)2D3, 1, 24(OH)2D); and other mineral-regulating hormones, including FGF23 in both intact (iFRG23) and inactive (C- terminal) forms.Objective: To clarify normal concentrations of minerals and hormones in healthy, preterm inf...

ba0002p60 | (1) | ICCBH2013

Failure of free, public vitamin D supplementation program for Quebec infants: temporal trends and significant predictors

Millette Maude , Sharma Atul , Weiler Hope , Sheehy Odile , Berard Anick , Rodd Celia

Over 80% of Quebec woman initiate breastfeeding, and rates of exclusive breastfeeding at 6 months doubled from 2003 (9.7%) to 2009 (19.0%). To prevent deficiency, current recommendations for these infants include 400 IU/day of vitamin D. For 20 years, Quebec has offered a program of free vitamin D supplements through its public medication insurance plan (RAMQ).Objective: Program evaluation over the last decade.Methods: This is a re...

ba0003pp339 | Osteoporosis: treatment | ECTS2014

Recommendations for osteoporosis management and fracture prevention for the frail elderly in long-term care

Papaioannou Alexandra , Santesso Nancy , Morin Suzanne , Cheung Angela , Crilly Richard , Giangregorio Lora , Jaglal Susan , Katz Paul , Josse Robert , Kaasalainen Sharon , Moser Andrea , Pickard Laura , Skidmore Carly , Weiler Hope , Whiting Susan , Jain Ravi , Adachi Jonathan

Objectives: Clinicians practicing in long-term care (LTC) face unique challenges caring for frail elderly individuals including multiple co-morbidities, polypharmacy, and end of life care, and practice guidelines typically do not address this population. Guidance regarding the management of osteoporosis and fracture prevention in LTC, a high-risk population, is needed.Materials and methods: A survey of LTC physicians informed key questions and outcomes, ...