Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp189 | Genetics | ECTS2014

A polymorphism in the TGF-β1 gene affects TGF-β1 secretion

Husted Lise , Sorensen Lotte , Stenkjaer Liselotte , Langdahl Bente

Transforming growth factor (TGF)-β1 is the most abundant growth factor in human bone. Several polymorphisms have been described in the TGF-β1 gene (TGFB1). We have previously shown that individuals with the CC genotype of the T29C polymorphism have higher bone mass at the femoral neck. The T29C polymorphism causes a change from leucine to proline at codon 10, which is located in the hydrophobic α-helical part of the signal peptide....

ba0003pp195 | Genetics | ECTS2014

Interactions between the effects of polymorphisms in the RANK and RANKL genes affects bone mass

Andersen Jane Dahl , Harslof Torben , Husted Lise , Langdahl Bente

Osteoporosis is a common disorder with a partly genetic pathogenesis. Interaction between RANKL and its receptor RANK is essential in bone remodeling.We therefore investigated the effect of polymorphisms in the RANK and RANKL genes and interaction between the effects on bone mineral density (BMD) and vertebral fractures.The study was a case-control study with 462 osteoporotic patients and 336 controls. Ten polymor...