Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp353 | Osteoporosis: treatment | ECTS2014

PTH treatment induces WNT10b expression in humans lymphoid cells

Patrizia D'Amelio , Sassi Francesca , Buondonno Ilaria , Spertino Elena , D'Amico Lucia , Roato Ilaria , Isaia Giovanni Carlo

Intermittent PTH reduces vertebral fractures risk in osteoporotic patients. The mechanisms trough which PTH acts are not completely understood, it has been observed to activate Wnt pathways in osteoblasts (OBs). Activation of this pathway induces OB proliferation, differentiation and prevents apoptosis. Recently increased expression of Wnt10b by T cells during intermittent PTH, and no increase during continuous PTH has been demonstrated in mice.In order to evaluate if PTH incr...

ba0005p127 | Cancer and bone: basic, translational and clinical | ECTS2016

LIGHT promotes osteolytic bone metastases in NSCLC patients

Brunetti Giacomina , Belisario Dimas Carolina , Alliod Valentina , Buffoni Lucio , Colucci Silvia , Grano Maria , Ferracini Riccardo , Roato Ilaria

LIGHT is a TNF superfamily member, expressed by activated T cells. It is involved in erosive bone disease, such as rheumatoid arthritis where it stimulates osteoclastogenesis. In multiple myeloma, LIGHT promotes osteolysis by increasing osteoclastogenesis and inhibiting osteoblastogenesis. We investigated whether LIGHT has a role in the osteolytic bone metastatic process induced by non small cell lung cancer (NSCLC), which is a tumor with a marked osteotropism. We analysed by ...