Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp166 | Cell biology: osteoblasts and bone formation | ECTS2013

Activated protein C increases osteoblast proliferation and BMP2 induced bone formation

Shen Kaitlin , Schindeler Aaron J , Cheng Tegan L , Xue Meilang , Little David G , Jackson Chris J

Introduction: Activated protein C (APC) plays an important role in the cutaneous healing of chronic wounds arising from orthopaedic surgery and has cytoprotective and anti-inflammatory properties which may also assist bone repair. The aim of this study was to examine whether APC could directly influence osteoblasts and increase bone formation in a rodent model.Methods: Proliferation of MG-63 osteoblast-like cells was quantified by MTT assay and direct co...