Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp120 | Cell biology: osteoblasts and bone formation | ECTS2014

Treatment with allopurinol and oxypurinol promotes osteoblast differentiation and increases bone formation

Orriss Isabel , Arnett Timothy , George Jacob , Witham Miles

Allopurinol and, and its active metabolite, oxypurinol are widely used in the treatment of gout and hyperuricemia. They act by inhibiting xanthine oxidase an enzyme in the purine degradation pathway that converts xanthine to uric acid. This oxygen-dependent reaction also results in the generation of superoxide free radicals. The aim of this investigation was to examine the effect of allopurinol and oxypurinol on osteoblast differentiation and function. Rat calvarial osteoblast...

ba0003pp299 | Osteoporosis: treatment | ECTS2014

Association between allopurinol use and hip fracture in older patients discharged from rehabilitation

Basu Ujani , Goodbrand James , McMurdo Marion , Donnan Peter , McGilchrist Mark , Frost Helen , George Jacob , Witham Miles

Background: Allopurinol reduces oxidative stress and interacts with purinergic signalling systems important in bone metabolism and muscle function. We assessed whether allopurinol use was associated with a reduced incidence of hip fracture in older people who had undergone rehabilitation.Methods: Analysis of prospective, routinely-collected rehabilitation and hospitalisation data. Data on patients discharged from a single inpatient geriatric rehabilitati...