Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p251 | Genetics and Epigenetics | ECTS2016

Establishment of an in vivo model to examine the osteoanabolic epigenome

Saito Hiroaki , Najafova Zeynab , Jahn Katharina , Taipaleenmaki Hanna , Gasser Andreas , Johnsen Steven A. , Hesse Eric

Increasing bone formation is an effective approach to prevent osteoporotic fractures. Although the intermittent administration of PTH is an established osteoanabolic therapy and an anti-Sclerostin antibody (Scle-AB) is currently being tested in phase 3 clinical trials, a great need exists for additional bone anabolic agents. Thus, in the context of a bi-national consortium we aim to uncover novel epigenomic networks controlling bone formation to identify new epigenomic approac...

ba0005p253 | Genetics and Epigenetics | ECTS2016

Investigating the osteoanabolic epigenome of aging-related bone loss in humans

Ring Matthias , Saito Hiroaki , Taipaleenmaki Hanna , Najafova Zeynab , Jahn Katharina , Gasser Andreas , Haasper Carl , Gessler Roland , Gehrke Thorsten , Johnsen Steven A. , Hesse Eric

During aging bone resorption often increases while bone formation decreases, thereby reducing bone mass and bone mineral density (BMD) and leading to osteoporosis. Evidence suggests that extrinsic factors may influence bone remodeling. While poorly understood, these mechanisms may function by inducing epigenomic programs that diminish the bone forming capacity of osteoblasts. This study is part of a bi-national consortium aimed at uncovering epigenomic networks controlling the...