Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp4 | Arthritis and other joint diseases: translational and clinical | ECTS2014

Phenotypic and functional characterization of osteoclast progenitors in circulatory and synovial compartments of patients with rheumatoid arthritis

Sucur Alana , Jajic Zrinka , Ikic Marina , Ivcevic Sanja , Kelava Tomislav , Grcevic Danka

Rheumatoid arthritis (RA) is marked by the persistent inflammation and osteodestruction, causing progressive disability. Osteoclast progenitors (OCPs) represent a subpopulation of peripheral blood monocytes and have been shown to be present in healthy subjects and arthritic patients. The aim of our study was to determine the phenotype, frequency and osteoclastogenic potential of OCPs in the peripheral blood and synovial fluid of RA patients in response to anti-TNF therapy....