Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp153 | Cell biology: osteoclasts and bone resorption | ECTS2014

Zoledronic acid differently affects long-bone and jaw bone remodeling

Vermeer Jenny A.F. , Renders Greetje A.P. , van Duin Marion A. , Jansen Ineke D.C. , Bakker Lieneke F. , Kroon Sophie A. , de Vries Teun J. , Everts Vincent

Bisphosphonates (BPs) are used to treat bone diseases characterized by excessive bone resorption. However, BPs can negatively affect the jaw bone by causing osteonecrosis of the jaw. Previously, we showed that BPs differently affect long-bone and jaw osteoclast precursors. Administration of BPs in vivo reduced the number of jaw bone marrow cells, without affecting long-bone marrow cells. Yet, BPs increased bone volume and mineral density of both long bone and jaw. Her...