Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp137 | Cell biology: osteoblasts and bone formation | ECTS2014

IGF1 stimulates protein synthesis by enhancing mRNA translation rate in osteoblasts

Bakker Astrid D. , Gakes Tom , Juffer Petra , Hogervorst Jolanda M.A. , de Wit Gerard M.J. , Klein-Nulend Jenneke , Jaspers Richard T.

IGF1 is an osteo-anabolic factor that stimulates osteogenic precursor cell differentiation. IGF1 is produced in bone in response to mechanical stimulation, but also in mechanically-stimulated muscle cells. IGF1 enhances the rate of mRNA translation in muscle cells via activation of the PI3K/AKT/mTOR pathway, thereby increasing in muscle mass. Therefore we hypothesized that IGF1 not just enhances osteogenic differentiation of precursors, but also stimulates protein syn...