Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p54 | Bone development/growth and fracture repair | ECTS2016

Role of interleukin-6 in the early and late fracture healing phase

Prystaz Katja , Kovtun Anna , Kaiser Kathrin , Heidler Verena , Kroner Jochen , Haffner-Luntzer Melanie , Ignatius Anita

Interleukin-6 (IL-6) plays an important role in bone metabolism and regulates fracture healing in a presently unknown process. In the fracture callus IL-6 expression is biphasic; it peaks during the inflammatory phase and again during intramembranous and endochondral ossification (Ai-Aql et al. 2008). Few studies using IL-6 knockout mice indicate that IL-6 might be crucial for bone healing (Yang et al. 2007). However, a generalized IL-6 knockout induces multi...