Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p254 | Genetics and Epigenetics | ECTS2016

Genetic risk factors for knee osteoarthritis in postmenopausal ukrainian women

Grygorieva Nataliia , Povoroznyuk Vladyslav , Kaliada Aleksander , Krochak Svyatoslava , Balatska Nataliya

Osteoarthritis is a complex pathogenesis because diverse factors interact causing a process of deterioration of the cartilage and the subchondral bone. Despite the multifactorial nature of the knee osteoarthritis, it is related to a strong genetic component. Determination of molecular genetic causes of osteoarthritis is an actual problem. There are several approaches to assess the contribution of a candidate gene in the pathogenesis of osteoarthritis. The aim of the study was ...

ba0005p255 | Genetics and Epigenetics | ECTS2016

Polymorphism of vitamin D receptor gene, estrogen receptor gene and collagen type I α1 gene for osteoporosis in Ukrainian women

Balatska Nataliya , Povoroznyuk Vladyslav , Grygorieva Nataliia , Kaliada Aleksander

Osteoporosis has a complex etiology and is considered a multifactorial polygenic disease in which genetic determinants are modulated by hormonal, environmental, and nutritional factors.Polymorphism of the vitamin D receptor gene has been reported to play a major role in variations for genetic regulation of bone mass but its role within various ethnic populations is not clear. Estrogens are known to play an important role in regulating bone homeostasis, t...