Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp19 | Arthritis and other joint diseases: translational and clinical | ECTS2013

Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis

Ebina Kosuke , Morimoto Tokimitsu , Shi Kenrin , Kaneshiro Shoichi , Koizumi Kota , Hirao Makoto , Hashimoto Jun , Yoshikawa Hideki

Objectives: Recent studies have demonstrated that vitamin K2 (VitK2) induces apoptosis of not only osteoclasts but also rheumatoid arthritis (RA) synovial cells in vitro, while its clinical effect on disease activity of RA remains unknown.Methods: 158 female RA patients (age 62.5 years, duration of disease 14.9 years) who had not been treated with warfarin, biologics, or teriparatide were enrolled in this study. VitK2 (45 mg/day) was administered orally ...