Searchable abstracts of presentations at key conferences on calcified tissues

ba0005oc6.4 | Development and differentiation (or Aging) | ECTS2016

Extranuclear effects of estrogen on cortical bone in males is dependent on estrogen receptor A activation function-1

Farman Helen , Wu Jianyao , Gustafsson Karin , Windahl Sara , Kim Sung , Katzenellenbogen John , Ohlsson Claes , Lagerquist Marie

Estradiol (E2) signaling via estrogen receptor alpha (ERα) is important for the male skeleton as demonstrated by ERα inactivation in both mice and man. ERα mediates estrogenic effects by translocating to the nucleus and there affects gene transcription, but some effects can also be mediated via extra-nuclear actions of the receptor by, e.g., triggering cytoplasmic signaling cascades. ERα contains various domains and the role of activation functio...