Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p59 | Bone development/growth and fracture repair | ECTS2016

Midkine is involved in the pathogenesis of delayed osteoporotic fracture healing after ovariectomy in mice

Haffner-Luntzer Melanie , Kemmler Julia , Heidler Verena , Prystaz Katja , Schinke Thorsten , Amling Michael , Ignatius Anita , Liedert Astrid

Previous studies demonstrated a negative influence of the growth- and differentiation factor midkine (MDK) on bone formation during bone remodeling and fracture healing. Additionally, MDK-deficiency protected mice from a loss of trabecular bone mass after ovariectomy (OVX). Therefore, we hypothesized that MDK may also be involved in the pathogenesis of delayed, osteoporotic fracture healing after OVX in mice. Thus, we analyzed the expression of MDK during bone regeneration and...