Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp157 | Cell biology: osteoclasts and bone resorption | ECTS2014

CCN2 induces osteoclastogenesis by regulating RANK/RANKL/OPG system

Aoyama Eriko , Kubota Satoshi , Nishida Takashi , Takigawa Masaharu

CCN family member 2(CCN2)/Connective tissue growth factor (CTGF) is a multi-functional factor in proliferation, differentiation and migration of mesenchymal cells such as chondrocytes, osteoblasts and vascular endothelial cells. Recently, we also reported that CCN2/CTGF promotes osteoclastgenesis via induction of and interaction with DC-STAMP. We and other researchers reported that CCN2 binds to cytokines and receptors and modified their signaling. Therefore, we compr...

ba0005p177 | Cell biology: osteoclasts and bone resorption | ECTS2016

A novel regulatory factor in osteoclastogenesis DCL-1/CD302: significance of its binding to CCN2/CTGF

Aoyama Eriko , Hoshijima Mitsuhiro , Kubota Satoshi , Takigawa Masaharu

CCN2/CTGF is known as a multi-functional growth factor for various mesenchymal cells including chondrocytes, osteoblasts, vascular endothelial cells and its function is suggested to be produced by its binding to other growth factors or membrane proteins. Therefore, finding out these binding partners are critically important in understanding the molecular function of the CCN2. As a result of screening, DCL-1/CD302 was found as a new candidate of CCN2-binding molecule. DCL-1/CD3...