Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp338 | Osteoporosis: treatment | ECTS2014

Patients at high risk of fragility fracture and teriparatide: report from a third level osteoporosis clinic

Bagnari Valentina , Bortoluzzi Alessandra , Corte Renato La , Govoni Marcello

Background: Osteoporotic fractures are a major cause of disability and results in extensive utilization of health care resources. The history of previous fractures increases the risk for future fragility fractures.Subject: To describe the diagnostic therapeutic protocol of our tertiary care clinic dedicated to the osteoporosis (OP) treatment. To estimate the use of effective therapies for OP in those patients at highest risk for future fracture.<p cl...

ba0001pp408 | Osteoporosis: treatment | ECTS2013

Vertebroplasty vs kyphoplasty in osteoporotic vertebral fractures: a finite element comparative analysis

Pietrogrande Luca , Ottardi Claudia , Barbera Luigi La , Raimondo Emanuela , Villa Tomaso

Introduction: Vertebroplasty (VP) and ballon kyphoplasty (BKP) are used in the treatment of the vertebral compression fractures (VCF), that usually result in a typical wedged deformation. It is still under debate which technique is the best, in terms of efficacy, costs, and safety, mainly about the risk of a adjacent new fractures. The aim of this study is to evaluate the biomechanical outcome of vertebroplasty and kyphoplasty by a computational comparative analysis with finit...

ba0003pp328 | Osteoporosis: treatment | ECTS2014

Effects of a preventive long duration treatment of ovariectomized rats with strontium ranelate and zoledronic acid on bone mineral density and bone remodeling

Gomez-Chinchon Marina , Martin-Fernandez Marta , Diaz-Curiel Manuel , De la Piedra Concepcion

Long-term use of pharmacological treatments of osteoporosis is currently a controversial subject within the scientific community.The aim of this work was to study the effects produced by a preventive long duration treatment of strontium ranelate and zoledronic acid on bone mass and remodelling when they are administered to ovariectomized rats.Sixty female albino Wistar rats were divided into four groups (n=15): SHAM group ...

ba0003pp250 | Osteoporosis: evaluation and imaging | ECTS2014

Vitamin D levels in male patients with systemic lupus erythematosus

Vergara Cristina , Martinez-Ferrer Angels , Vicens Elvira , Valls Elia , Oller Jose , De la Morena Isabel , Ybanez Desamparados , Alegre Juan Jose

Introduction: Although systemic lupus erythematosus (SLE) has traditionally been considered a disease of women, men may also be afected. Male osteoporosis is increasingly recognised. Several studies have reported that mean bone mineral density is significantly reduced in SLE women patients and most of them have low levels of vitamin D. The aim of our study is to analize this situation in men.Objectives: Determine 25-hydroxyvitamin-D (25OHD) serum concent...

ba0003pp320 | Osteoporosis: treatment | ECTS2014

Effects of preventive long-term treatment with strontium ranelate and zoledronic acid to ovariectomized rats on bone microstructure

Martin-Fernandez Marta , Gomez-Chinchon Marina , Guede David , Caeiro Jose Ramon , Diaz-Curiel Manuel , De la Piedra Concepcion

Many pharmacological treatments have been developed in order to prevent or treat postmenopausal osteoporosis. There is not any study in the literature comparing long-term treatments of osteoporosis. The aim of this work was to studythe effects of long-term prevention treatment with zoledronic acid (ZA) and strontium ranelate (SrR) on bone microstructure in ovariectomized rats.Sixty 6-month-old female Wistar rats were used in this study and divided into f...

ba0005p277 | Nutrition | ECTS2016

Association between the sideways fall fractures and body mass index in patients from a public Mexican hospital

Pacheco-Pantoja Elda , Garcia-Ojeda Marycruz , Ramos-Pereyra Viridiana , Sanchez-de-la-Cruz Cindy , Diaz-Diaz Cristel , Osorio-Merito Nallely

The body mass index has been regarded as a risk predictor factor for fractures, and in some prospective cohort studies it has been suggested that obesity could be a protective factor for hip fractures in adults.The present study aimed to investigate whether body mass index is related to the fracture risk when individuals had sideways falls in Mexican patients. We analyzed files from 448 patients, which checked in at Orthopedics and Traumatology Service i...

ba0006p046 | (1) | ICCBH2017

A 16 years old follow up in one case of congenital multiple hormone deficiency: growth, sexual development and bone metabolism

Petrolini Chiara , Stagi Stefano , Rubino Chiara , Gioe Daniela , Spina Luisa La , Peluso Francesca , Monica Matteo Della , Martino Maurizio de

Background: Congenital multiple hormone deficiency (CMHD) is a rare condition caused by mutations in transcription factors involved in pituitary ontogenesis1. Incidence of mutations in POU1F1 gene in results between 3.8 and 7.7%2. POU1F1 gene mutations lead to somatolactotroph and thryotroph deficiencies. Brain MRI can be normal or shows pituitary hypoplasia without extrapituitary anomalies.Presenting problem: We describe the growth...

ba0006p119 | (1) | ICCBH2017

Phenotypic spectrum in Weyers acrofacial dysostosis: A case report

Rubino Chiara , Stagi Stefano , Petrolini Chiara , Gioe Daniela , La Spina Luisa , Peluso Francesca , Della Monica Matteo , de Martino Maurizio

Background: Weyers acrofacial dysostosis (WAD, OMIM 193530) is a rare autosomal dominant disease, characterized by mildly short stature, postaxial polydactyly, nail dystrophy and dental anomalies. WAD should be distinguished from Ellis-van Creveld syndrome (OMIM 225500), a similar but more severe disease, comprising chondrodysplasia, orofacial anomalies and, in a proportion of patients, cardiovascular malformations. Both diseases are caused by mutations in either EVC or EVC2<s...

ba0003pp390 | Other diseases of bone and mineral metabolism | ECTS2014

Bone marrow densitometry by clinical high resolution computed tomography of human vertebrae

Vergara Cristina , Martinez-Ferrer Angels , Fernandez Miguel , Vicens Elvira , Ybanez Desamparados , Valls Elia , De la Morena Isabel , Oller Jose , Alegre Juan Jose

Introduction: Gaucher disease (GD), the most prevalent glycolipid storage disease, is an autosomal recessive metabolic disorder that is caused by an inherited deficiency of the lysosomal enzyme, glycocerebrosidase. This defect leads to reduce enzyme activity, resulting in the accumulation of glucosylceramide in cells of the monocyte-macrophages linage, known as Gaucher cells. Common presenting features include anemia, thrombocytopenia, hepatosplenomegaly and bone abnormalities...

ba0005p17 | Biochemical testing | ECTS2016

Effects of subcutaneous administration of caffeine on bone markers in rats

Lopez-Rivas Victor , Murillo-Rodriguez Eric , Jimenez-Moreno Ramses , Poot-Ake Alwin , de-la-Cruz-Delgado Miriel , Ellis-Infante Nicole , Pacheco-Pantoja Elda

There is some evidence that caffeine consumption has effects on bone mineral metabolism, however the reports in this regard show some ambiguity. Being this compound one of the most popular for human consumption in the world, we analyzed the effects of soluble caffeine subcutaneous administration on serum osteocalcin and serum bone alkaline phosphatase (bALP) in Wistar male rats (weighting 200–250 g). Variable doses were used (30, 75, 150 mg/kg), during 30 days. The animal...