Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp464 | Other diseases of bone and mineral metabolism | ECTS2013

Effects of add-on parathyroid hormone (PTH(1-84)) substitution therapy in hypoparathyroidism: results from 2.5 years of PTH treatment

Sikjaer Tanja , Moser Emil , Rolighed Lars , Mosekilde Leif , Rejnmark Lars

Conventional treatment of hypoparathyroidism with calcium and active vitamin D analogues causes a high renal calcium excretion and over-mineralized bone.We studied 62 patients with hypoPT randomized to 6 months of treatment with either parathyroid hormone (PTH(1-84)) 100 μg/d s.c. or similar placebo, administered as an add-on therapy. Forty-two of the patients had follow-up test performed after 2.5 years; 9 patients had continued daily PTH treatment...

ba0003pp121 | Cell biology: osteoblasts and bone formation | ECTS2014

Is the bone marrow envelope a reservoir of osteoblast progenitors?

Kristensen Helene Bjoerg , Andersen Thomas Levin , Marcussen Niels , Rolighed Lars , Delaisse Jean-Marie

It is still unknown where from osteoblasts are recruited during remodeling of adult human cancellous bone. Still, it is often suggested that they originate from perivascular osteoprogenitors in the bone marrow (BM). Here we propose also the existence of a layer of osteoprogenitors at the periphery of the BM. This proposal is based on electron and light microscopy of the bone surface and of the neighboring BM in human iliac crest biopsies, where we quantified cell densities, ce...

ba0003pp210 | Muscle, physical activity and bone | ECTS2014

No beneficial effects of vitamin D supplementation in muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial

Rolighed Lars , Rejnmark Lars , Sikjaer Tanja , Heickendorff Lene , Vestergaard Peter , Mosekilde Leif , Christiansen Peer

Context: Impairment of muscle function and strength in patients with primary hyperparathyroidism (PHPT) is rarely addressed although decreased muscle function may contribute to increased fracture risk in PHPT.Objective: We aimed to assess changes in muscle strength, muscle function, postural balance, quality of life (QoL), and well-being during treatment with vitamin D or placebo before and after parathyroidectomy (PTX) in PHPT patients.<p class="abs...

ba0005p429 | Other diseases of bone and mineral metabolism | ECTS2016

Impaired quality of life and muscle function in patients with hypoparathyroidism/hypothyroidism compared with only hypothyroidism and controls

Sikjaer Tanja , Moser Emil , Rolighed Lars , Underbjerg Line , Bislev Lise , Mosekilde Leif , Rejnmark Lars

Total thyroidectomy causes postsurgical hypothyroidism (HypoT). Besides HypoT, patients may also develop hypoparathyroidism (HypoPT).The aim of the study was to assess Quality of Life (QoL), muscle function, and bone indices in patients with postsurgical hypothyroidism and hypoparathyroidism (HypoT+PT) as compared to patients with postsurgical HypoT and healthy controls.Age and gender matched patients on treatment for HypoT+PT and ...

ba0001pp286 | Muscle, physical activity and bone | ECTS2013

Muscle function and quality of life in primary hyperparathyroidism

Rolighed Lars , Amstrup Anne Kristine , Jakobsen Niels Frederik Breum , Sikjaer Tanja , Mosekilde Leif , Christiansen Peer , Rejnmark Lars

Introduction: In spite of the frequent encounter of ‘asymptomatic’ primary hyperparathyroidism (PHPT), the patients often describe various relevant improvements postoperatively suggesting a subclinical biological effect of elevated PTH or hypercalcaemia.Materials and methods: To evaluate muscle function, postural stability, and quality of life (QoL) in untreated PHPT, we assessed maximal isometric muscle strength in upper and lower extremities,...