Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp169 | Cell biology: osteoclasts and bone resorption | ECTS2014

Mechanosensitive TRP channels are required for Ca2+ signaling in osteoclastogenesis

Yang Yu-Mi , Lee Jiae , Shin Dong Min

Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. RANKL (receptor activator of NF-kB ligand) induces Ca2+ oscillations and activates NFATc1 (nuclear factor of activated T cells i) during osteoclast differentiation. Although Ca2+ oscillations play a key role for osteoclastogenesis...