Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp131 | Cell biology: osteoblasts and bone formation | ECTS2014

Hyperbaric oxygen promotes osteogenic differentiation of mesenchymal stem cells by regulating sclerostin expression and Wnt/β-catenin signaling

Lin Song-Shu , Ueng Ueng Steve W.N. , Niu Chi-Chien , Yuan Li-Jen , Yang Chuen-Yung , Chen Wen-Jer , Lee Mel S. , Chen Jan-Kan

Background: Hypoxia induces mesenchymal stem cells (MSCs) proliferation but results in a population with impaired osteogenic differentiation potential. Bone healing of tibial lengthening is enhanced by hyperbaric oxygen therapy. However, little is known about the effects of HBO on the Wnt signaling pathway in MSCs.Materials and methods: MSCs were cultured in complete medium and the osteogenic groups were cultured in osteogenic induction medium. Control c...